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2018 Apr 12
indicating that Syk kinase is the primary target of R112
7 μM) and glycogen synthase kinase 3β (GSK3β) (IC50=11
12-tetraoxatetradecanamido)-2-(((R)-1
It also significantly blocks cancer stem cell (CSC) properties in cells with high YAP1 and a high proportion of ALDH1(+)
β-Hydroxyisovalerylshikonin - CAS# 7415-78-3 te disodium 2018 Apr 12Beta hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0. 7M and 1M for EGFR and v Src receptor, respectively. Beta hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell death in NCI H522 and DMS114 cells. Product information CAS Number: 7415 78 3 Molecular Weight: 388. 41 Formula: